Construct a well built clinical question derived from the case. The most commonly used model for clinical questions is PICO.
For more on constructing a good question, visit the Resources for Evidence-Based Practice Guide: Forming Questions.
Select the appropriate resource(s)....
How do you find the best research evidence when there are millions of articles, journals and clinical guidelines to choose from? Using a hierarchy of "pre-processed" information can be very useful for selecting resources. See our Resources for Evidence-based Practice Guide for more on the 6S Pyramid of evidence.
...and conduct a search.
Depending on the resource you've selected to search, you will apply your question's concepts in different ways. When searching a large database of articles, such as OVID Medline, you'll need more advanced searching skills. Try watching some of our Database searching tutorials to help you with your search.
Appraise that evidence for its validity and applicability. Below are two very useful resources for appraising the validity of the resources and evidence you've acquired.